Discover Magical MontepulcianoMontepulciano is a medieval and Renaissance hill town and comune in the Italian province of Siena in southern Tuscany. It sits high on a 605-metre (1,985 ft) limestone ridge, 13 kilometres (8 mi) east of Pienza, 70 kilometres (43 mi) southeast of Siena, 124 kilometres (77 mi) southeast of Florence.